Identification of a novel tumor angiogenesis inhibitor targeting Shh/Gli1 signaling pathway in Non-small cell lung cancer

Safety and Tolerability of Sonic Hedgehog Pathway Inhibitors in Cancer

(2019) Richard L. Carpenter et al.   DRUG SAFETY

Targeting Hedgehog signaling pathway: paving the road for cancer therapy

(2019) Ioana Berindan-Neagoe et al.   PHARMACOLOGICAL RESEARCH

Ginsenoside F1 promotes angiogenesis by activating the IGF-1/IGF1R pathway

(2019) Jiayan Zhang et al.   PHARMACOLOGICAL RESEARCH

Dynamic Interplay between Pericytes and Endothelial Cells during Sprouting Angiogenesis

(2019) Giulia Chiaverina et al.   Cells

HDAC6 inhibition induces glioma stem cells differentiation and enhances cellular radiation sensitivity through the SHH/Gli1 signaling pathway

(2018) Wei Yang et al.   CANCER LETTERS

A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer

(2018) Buse Cevatemre et al.   PHARMACOLOGICAL RESEARCH

Comprehensive immunohistochemical analyses on expression levels of hedgehog signaling molecules in breast cancers

(2018) Junichi Kurebayashi et al.   Breast Cancer

Desacetylvinblastine Monohydrazide Disrupts Tumor Vessels by Promoting VE-cadherin Internalization

(2018) Xueping Lei et al.   Theranostics

The hierarchical micro-/nanotextured topographies promote the proliferation and angiogenesis-related genes expression in human umbilical vein endothelial cells by initiation of Hedgehog-Gli1 signaling

(2018) Yao Lin et al.   Artificial Cells Nanomedicine and Biotechnology

Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents

(2017) Minfeng Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Administration of sonic hedgehog protein induces angiogenesis and has therapeutic effects after stroke in rats

(2017) Sheng-cai Chen et al.   NEUROSCIENCE

Anti-cancer effect of pristimerin by inhibition of HIF-1α involves the SPHK-1 pathway in hypoxic prostate cancer cells

(2016) Seon-Ok Lee et al.   BMC CANCER

Pristimerin triggers AIF-dependent programmed necrosis in glioma cells via activation of JNK

(2016) Hongwei Zhao et al.   CANCER LETTERS

Angiogenesis inhibitors as therapeutic agents in cancer: Challenges and future directions

(2016) Zhexuan Lin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting prion-like protein doppel selectively suppresses tumor angiogenesis

(2016) Taslim A. Al-Hilal et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

(2016) N. N. Rahbari et al.   Science Translational Medicine

Pristimerin inhibits angiogenesis in adjuvant-induced arthritic rats by suppressing VEGFR2 signaling pathways

(2015) Qiudi Deng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Tumor angiogenesis, from foe to friend

(2015) L. B. Rivera et al.   SCIENCE

Sonic Hedgehog and Gli1 Expression Predict Outcome in Resected Pancreatic Adenocarcinoma

(2015) R. Marechal et al.   CLINICAL CANCER RESEARCH

A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance

(2014) Z. Liu et al.   BLOOD

Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer

(2013) Sampurna Chatterjee et al.   JOURNAL OF CLINICAL INVESTIGATION

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

(2013) Dereck Amakye et al.   NATURE MEDICINE

Discovery of PG545: A Highly Potent and Simultaneous Inhibitor of Angiogenesis, Tumor Growth, and Metastasis

(2012) Vito Ferro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pristimerin, a Triterpenoid, Inhibits Tumor Angiogenesis by Targeting VEGFR2 Activation

(2012) Xianmin Mu et al.   MOLECULES

Sonic Hedgehog Pathway Promotes Metastasis and Lymphangiogenesis via Activation of Akt, EMT, and MMP-9 Pathway in Gastric Cancer

(2011) Y. A. Yoo et al.   CANCER RESEARCH

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE