Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

(2019) Richard Karlsson Linnér et al.   NATURE GENETICS

Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium

(2018) Jordi Merino et al.   MOLECULAR PSYCHIATRY

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

(2018) Hilary K. Finucane et al.   NATURE GENETICS

Was there ever really a “sugar conspiracy”?:

(2018) David Merritt Johns et al.   SCIENCE

History of modern nutrition science—implications for current research, dietary guidelines, and food policy

(2018) Dariush Mozaffarian et al.   BMJ-British Medical Journal

History of modern nutrition science—implications for current research, dietary guidelines, and food policy

(2018) Dariush Mozaffarian et al.   BMJ-British Medical Journal

The Physical Activity Guidelines for Americans

(2018) Katrina L. Piercy et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition

(2017) Kevin D. Hall et al.   GASTROENTEROLOGY

Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women

(2017) Silvia Stringhini et al.   LANCET

Fructose Metabolism from a Functional Perspective: Implications for Athletes

(2017) Luc Tappy et al.   SPORTS MEDICINE

High protein intake in young children and increased weight gain and obesity risk1

(2016) Berthold Koletzko et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

(2016) Jie Zheng et al.   BIOINFORMATICS

The Sweetest Thing: Regulation of Macronutrient Preference by FGF21

(2016) Andrew C. Adams et al.   Cell Metabolism

FGF21 Regulates Sweet and Alcohol Preference

(2016) Saswata Talukdar et al.   Cell Metabolism

FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver

(2016) Stephanie von Holstein-Rathlou et al.   Cell Metabolism

Molecular Genetic Contributions to Social Deprivation and Household Income in UK Biobank

(2016) W. David Hill et al.   CURRENT BIOLOGY

Controversies about sugars: results from systematic reviews and meta-analyses on obesity, cardiometabolic disease and diabetes

(2016) Tauseef A. Khan et al.   EUROPEAN JOURNAL OF NUTRITION

Protein intake in early childhood and body composition at the age of 6 years: The Generation R Study

(2016) T Voortman et al.   INTERNATIONAL JOURNAL OF OBESITY

Genome-wide association study identifies 74 loci associated with educational attainment

(2016) Aysu Okbay et al.   NATURE

Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

(2016) Aysu Okbay et al.   NATURE GENETICS

A new frontier in FGF21 biology

(2016) Matthew J. Potthoff   Nature Reviews Endocrinology

Nutritional interventions or exposures in infants and children aged up to 3 years and their effects on subsequent risk of overweight, obesity and body fat: a systematic review of systematic reviews

(2016) B. Patro-Gołąb et al.   Obesity Reviews

KLBis associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

(2016) Gunter Schumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cohort profile of the UK Biobank: diagnosis and characteristics of cerebrovascular disease

(2016) J Hewitt et al.   BMJ Open

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

(2016) Luigi Fontana et al.   Cell Reports

Exercise performed immediately after fructose ingestion enhances fructose oxidation and suppresses fructose storage1

(2015) Léonie Egli et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dietary protein intake is associated with body mass index and weight up to 5 y of age in a prospective cohort of twins1,2

(2015) Laura Pimpin et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The 2015 US Dietary Guidelines

(2015) Dariush Mozaffarian et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

Gene expression analysis identifies global gene dosage sensitivity in cancer

(2015) Rudolf S N Fehrmann et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Fructose–Glucose Composite Carbohydrates and Endurance Performance: Critical Review and Future Perspectives

(2015) David S. Rowlands et al.   SPORTS MEDICINE

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

Lower protein content in infant formula reduces BMI and obesity risk at school age: follow-up of a randomized trial

(2014) Martina Weber et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Can We Say What Diet Is Best for Health?

(2014) D.L. Katz et al.   Annual Review of Public Health

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

(2014) Samantha M. Solon-Biet et al.   Cell Metabolism

Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

(2014) Morgan E. Levine et al.   Cell Metabolism

Long-Term Effects of 4 Popular Diets on Weight Loss and Cardiovascular Risk Factors: A Systematic Review of Randomized Controlled Trials

(2014) R. Atallah et al.  

Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study

(2014) Monique van Nielen et al.   DIABETES CARE

Physical Activity Offsets the Negative Effects of a High-Fructose Diet

(2014) Amy J. Bidwell et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

(2014) M C Cornelis et al.   MOLECULAR PSYCHIATRY

Quality control and conduct of genome-wide association meta-analyses

(2014) Thomas W Winkler et al.   Nature Protocols

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

(2013) Toshiko Tanaka et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Long-term health benefits of physical activity – a systematic review of longitudinal studies

(2013) Miriam Reiner et al.   BMC PUBLIC HEALTH

Novel locus including FGF21 is associated with dietary macronutrient intake

(2013) Audrey Y. Chu et al.   HUMAN MOLECULAR GENETICS

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

The Reactome pathway knowledgebase

(2013) David Croft et al.   NUCLEIC ACIDS RESEARCH

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

(2013) Danielle Welter et al.   NUCLEIC ACIDS RESEARCH

Macronutrient Composition of the Diet and Prospective Weight Change in Participants of the EPIC-PANACEA Study

(2013) Anne-Claire Vergnaud et al.   PLoS One

GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

(2013) C. A. Rietveld et al.   SCIENCE

Dietary sugars and body weight: systematic review and meta-analyses of randomised controlled trials and cohort studies

(2013) L. Te Morenga et al.   BMJ-British Medical Journal

Protein intake from 0 to 18 years of age and its relation to health: a systematic literature review for the 5th Nordic Nutrition Recommendations

(2013) Agneta Hörnell et al.   Food & Nutrition Research

Fructose toxicity

(2012) Luc Tappy et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Public health: The toxic truth about sugar

(2012) Robert H. Lustig et al.   NATURE

Neural and metabolic regulation of macronutrient intake and selection

(2012) Hans-Rudolf Berthoud et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Shared genetic contributions of fruit and vegetable consumption with BMI in families 20 y after sharing a household

(2011) Lisa J Martin et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effects of a restricted elimination diet on the behaviour of children with attention-deficit hyperactivity disorder (INCA study): a randomised controlled trial

(2011) Lidy M Pelsser et al.   LANCET

Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption

(2011) Marilyn C. Cornelis et al.   PLoS Genetics

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Can infant feeding choices modulate later obesity risk?

(2009) Berthold Koletzko et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Misreporting of energy and micronutrient intake estimated by food records and 24 hour recalls, control and adjustment methods in practice

(2009) Kamila Poslusna et al.   BRITISH JOURNAL OF NUTRITION

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis

(2009) Daniel I. Chasman et al.   PLoS Genetics

The Common P446L Polymorphism in GCKR Inversely Modulates Fasting Glucose and Triglyceride Levels and Reduces Type 2 Diabetes Risk in the DESIR Prospective General French Population

(2008) M. Vaxillaire et al.   DIABETES

Studies of Twins Indicate That Genetics Influence Dietary Intake

(2008) Ann Louise Hasselbalch et al.   JOURNAL OF NUTRITION