Is Alzheimer’s Disease a Liver Disease of the Brain?

Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition

(2019) Carine Z. J. Lim et al.   Nature Communications

The current state and future directions of RNAi-based therapeutics

(2019) Ryan L. Setten et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

ApoE4: an emerging therapeutic target for Alzheimer’s disease

(2019) Mirna Safieh et al.   BMC Medicine

Silymarin’s Inhibition and Treatment Effects for Alzheimer’s Disease

(2019) Hong Guo et al.   MOLECULES

Alpha-Synuclein Pathology and the Role of the Microbiota in Parkinson’s Disease

(2019) Emily Fitzgerald et al.   Frontiers in Neuroscience

A Novel PSEN1 M139L Mutation Found in a Chinese Pedigree with Early-Onset Alzheimer’s Disease Increases Aβ42/Aβ40 ratio

(2019) Qiongqiong Qiu et al.   JOURNAL OF ALZHEIMERS DISEASE

SILK studies — capturing the turnover of proteins linked to neurodegenerative diseases

(2019) Ross W. Paterson et al.   Nature Reviews Neurology

Performance of Fully Automated Plasma Assays as Screening Tests for Alzheimer Disease–Related β-Amyloid Status

(2019) Sebastian Palmqvist et al.   JAMA Neurology

Glymphatics visualization after focused ultrasound induced blood‐brain barrier opening in humans

(2019) Ying Meng et al.   ANNALS OF NEUROLOGY

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

The Emerging Relationship Between Interstitial Fluid–Cerebrospinal Fluid Exchange, Amyloid-β, and Sleep

(2018) Erin L. Boespflug et al.   BIOLOGICAL PSYCHIATRY

Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

High performance plasma amyloid-β biomarkers for Alzheimer’s disease

(2018) Akinori Nakamura et al.   NATURE

Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis

(2018) Merrill D. Benson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Probing the role of PPARγ in the regulation of late-onset Alzheimer’s disease-associated genes

(2018) Julio Barrera et al.   PLoS One

Therapeutic Genome Editing With CRISPR/Cas9 in a Humanized Mouse Model Ameliorates α1-antitrypsin Deficiency Phenotype

(2018) Mikael Bjursell et al.   EBioMedicine

Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer’s dementia subjects

(2018) James R. Goodman et al.   BRAIN BEHAVIOR AND IMMUNITY

Impaired Lipoprotein Receptor-Mediated Peripheral Binding of Plasma Amyloid-β is an Early Biomarker for Mild Cognitive Impairment Preceding Alzheimer's Disease

(2018) Abhay P. Sagare et al.   JOURNAL OF ALZHEIMERS DISEASE

Impaired hepatic amyloid-beta degradation in Alzheimer’s disease

(2018) Chera L. Maarouf et al.   PLoS One

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers

(2018) Kwangsik Nho et al.   Alzheimers & Dementia

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

(2018) Siamak MahmoudianDehkordi et al.   Alzheimers & Dementia

Recent Advances in Oligonucleotide-Based Therapy for Transthyretin Amyloidosis: Clinical Impact and Future Prospects

(2018) Yuya Hayashi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Tissue-Specific Metabolomics Analysis Identifies the Liver as a Major Organ of Metabolic Disorders in Amyloid Precursor Protein/Presenilin 1 Mice of Alzheimer’s Disease

(2018) Hong Zheng et al.   JOURNAL OF PROTEOME RESEARCH

The glymphatic pathway in neurological disorders

(2018) Martin Kaag Rasmussen et al.   LANCET NEUROLOGY

Effects of pioglitazone on the incidence of dementia in patients with diabetes

(2017) Ping-Song Chou et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

(2017) Axel Montagne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CPEB4 links the clock and the UPR to protect the liver

(2017) Paul C. Moore et al.   NATURE CELL BIOLOGY

Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage

(2017) William J. Netzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease

(2017) Julie M. Zissimopoulos et al.   JAMA Neurology

Hepatitis C virus infection, and neurological and psychiatric disorders – A review

(2017) Lydia Yarlott et al.   Journal of Advanced Research

APOE Genotype Results in Differential Effects on the Peripheral Clearance of Amyloid-β42 in APOE Knock-in and Knock-out Mice

(2017) Matthew J. Sharman et al.   JOURNAL OF ALZHEIMERS DISEASE

Comorbidity and dementia: A nationwide survey in Taiwan

(2017) Ting-Bin Chen et al.   PLoS One

Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease

(2017) Kelsey E. Jarrett et al.   Scientific Reports

High dietary advanced glycation end products are associated with poorer spatial learning and accelerated Aβ deposition in an Alzheimer mouse model

(2016) Irit Lubitz et al.   AGING CELL

The unfolded protein response: mechanisms and therapy of neurodegeneration

(2016) Heather L. Smith et al.   BRAIN

Recommendations for Management of Clinically Significant Drug-Drug Interactions With Statins and Select Agents Used in Patients With Cardiovascular Disease: A Scientific Statement From the American Heart Association

(2016) Barbara S. Wiggins et al.   CIRCULATION

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Pioglitazone for the treatment of Alzheimer’s disease

(2016) Daniela Galimberti et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Association between Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease, APOE Genotypes and Auditory Verbal Learning Task in Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer’s Disease

(2016) Monika Mandecka et al.   JOURNAL OF ALZHEIMERS DISEASE

Clearing Amyloid-β through PPARγ/ApoE Activation by Genistein is a Treatment of Experimental Alzheimer’s Disease

(2016) Vicent Bonet-Costa et al.   JOURNAL OF ALZHEIMERS DISEASE

Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

(2016) Do-Geun Kim et al.   Journal of Neuroinflammation

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1–40 brain-to-blood efflux and peripheral uptake transport

(2016) Y.-X. Guo et al.   NEUROSCIENCE

Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1?

(2016) Mobina Alemi et al.   Scientific Reports

Drug development in Alzheimer’s disease: the path to 2025

(2016) Jeffrey Cummings et al.   Alzheimers Research & Therapy

siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes

(2015) Shigeo Matsuda et al.   ACS Chemical Biology

Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease

(2015) Yang Xiang et al.   ACTA NEUROPATHOLOGICA

Plasma levels of apolipoprotein E and risk of dementia in the general population

(2015) Katrine L. Rasmussen et al.   ANNALS OF NEUROLOGY

Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

(2015) A. E. Elia et al.   EUROPEAN JOURNAL OF NEUROLOGY

Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice

(2015) Rebecca Skerrett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier

(2015) Steffen E. Storck et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

(2015) Stacy Steinberg et al.   NATURE GENETICS

Lipoprotein-Based Nanoparticles Rescue the Memory Loss of Mice with Alzheimer’s Disease by Accelerating the Clearance of Amyloid-Beta

(2014) Qingxiang Song et al.   ACS Nano

Amyloid-β efflux from the central nervous system into the plasma

(2014) Kaleigh Filisa Roberts et al.   ANNALS OF NEUROLOGY

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing

(2014) Qiurong Ding et al.   CIRCULATION RESEARCH

Activity of P-Glycoprotein, a  -Amyloid Transporter at the Blood-Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease

(2014) A. K. Deo et al.   JOURNAL OF NUCLEAR MEDICINE

Apolipoprotein E Likely Contributes to a Maturation Step of Infectious Hepatitis C Virus Particles and Interacts with Viral Envelope Glycoproteins

(2014) J.-Y. Lee et al.   JOURNAL OF VIROLOGY

Depressive symptoms in chronic hepatitis C are associated with plasma apolipoprotein E deficiency

(2014) David A. Sheridan et al.   METABOLIC BRAIN DISEASE

Diabetes Mellitus and the Risk of Alzheimer’s Disease: A Nationwide Population-Based Study

(2014) Chin-Chou Huang et al.   PLoS One

Alzheimer’s disease: relevant molecular and physiopathological events affecting amyloid-β brain balance and the putative role of PPARs

(2014) Juan M. Zolezzi et al.   Frontiers in Aging Neuroscience

In-Vivo Quantitative Proteomics Reveals a Key Contribution of Post-Transcriptional Mechanisms to the Circadian Regulation of Liver Metabolism

(2014) Maria S. Robles et al.   PLoS Genetics

LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's disease in humans in-vivo

(2014) Timo Grimmer et al.   NeuroImage-Clinical

Imatinib treatment and Aβ42 in humans

(2013) Bob Olsson et al.   Alzheimers & Dementia

Hepatitis C viral infection and the risk of dementia

(2013) W.-C. Chiu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Increase of beta-amyloid and C-reactive protein in liver transplant recipients with postoperative cognitive dysfunction

(2013) Xing Li et al.   Hepatobiliary & Pancreatic Diseases International

A Lipoprotein Receptor Cluster IV Mutant Preferentially Binds Amyloid-β and Regulates Its Clearance from the Mouse Brain

(2013) Abhay P. Sagare et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sleep duration and quality in relation to non-alcoholic fatty liver disease in middle-aged workers and their spouses

(2013) Chan-Won Kim et al.   JOURNAL OF HEPATOLOGY

Liver as a target for oligonucleotide therapeutics

(2013) Alfica Sehgal et al.   JOURNAL OF HEPATOLOGY

Dietary glycotoxins exacerbate progression of experimental fatty liver disease

(2013) Christopher Leung et al.   JOURNAL OF HEPATOLOGY

Synthesis and Identification of New Flavonoids Targeting Liver X Receptor β Involved Pathway as Potential Facilitators of Aβ Clearance with Reduced Lipid Accumulation

(2013) Yun Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Association between the characteristics of metabolic syndrome and Alzheimer’s disease

(2013) Hui-Ting Yang et al.   METABOLIC BRAIN DISEASE

The hypolipidemic effect of cilostazol can be mediated by regulation of hepatic low-density lipoprotein receptor-related protein 1 (LRP1) expression

(2013) Hyung Jun Kim et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver

(2013) D. Mauvoisin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Signaling by Nuclear Receptors

(2013) R. Sever et al.   Cold Spring Harbor Perspectives in Biology

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

(2012) Huilin Shao et al.   NATURE MEDICINE

Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice

(2012) Adrian C. Lo et al.   NEUROBIOLOGY OF DISEASE

Low-density lipoprotein receptor-related protein 1: A physiological Aβ homeostatic mechanism with multiple therapeutic opportunities

(2012) Abhay P. Sagare et al.   PHARMACOLOGY & THERAPEUTICS

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood A  clearance in a mouse model of  -amyloidosis

(2012) J. M. Castellano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

(2012) N. Sehgal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

From the liver to the blood-brain barrier: An interconnected system regulating brain amyloid-β levels

(2011) Abhay P. Sagare et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Peripheral reduction of β-amyloid is sufficient to reduce brain β-amyloid: Implications for Alzheimer's disease

(2011) J. Gregor Sutcliffe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

(2011) E Genin et al.   MOLECULAR PSYCHIATRY

Specialization, Subspecialization, and Subsubspecialization in Internal Medicine

(2011) Christine K. Cassel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lack of LDL Receptor Enhances Amyloid Deposition and Decreases Glial Response in an Alzheimer's Disease Mouse Model

(2011) Loukia Katsouri et al.   PLoS One

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Silymarin Attenuated the Amyloid β Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer’s Disease Mouse Model

(2010) Nakaba MURATA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain

(2010) Berislav V. Zlokovic et al.   JOURNAL OF NEUROCHEMISTRY

Antisense technology to lower LDL cholesterol

(2010) R Dermot G Neely et al.   LANCET

Up-regulation of hepatic low-density lipoprotein receptor–related protein 1: a possible novel mechanism of antiatherogenic activity of hydroxymethylglutaryl–coenzyme A reductase inhibitor

(2010) Jae Hoon Moon et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE

(2010) Rita J. Guerreiro et al.   NEUROBIOLOGY OF AGING

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE