Degradation of tumour stromal hyaluronan by small extracellular vesicle-PH20 stimulates CD103+ dendritic cells and in combination with PD-L1 blockade boosts anti-tumour immunity

Fragmented hyaluronan has no alarmin function assessed in arthritis synovial fibroblast and chondrocyte cultures

(2018) Mia Olsson et al.   Innate Immunity

IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor

(2018) Keishi Adachi et al.   NATURE BIOTECHNOLOGY

The Role of Toll-Like Receptor in Inflammation and Tumor Immunity

(2018) Xiaohong Cen et al.   Frontiers in Pharmacology

Engineering Exosomes for Cancer Therapy

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes in Cancer Nanomedicine and Immunotherapy: Prospects and Challenges

(2017) Nicholas L. Syn et al.   TRENDS IN BIOTECHNOLOGY

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Critical Role for CD103 + /CD141 + Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

(2016) Edward W. Roberts et al.   CANCER CELL

Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade

(2016) Haidong Tang et al.   CANCER CELL

Dual Faces of IFN  in Cancer Progression: A Role of PD-L1 Induction in the Determination of Pro- and Antitumor Immunity

(2016) M. Mandai et al.   CLINICAL CANCER RESEARCH

Hyaluronic acid in digestive cancers

(2016) Ruo-Lin Wu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery

(2016) Dominique Ingato et al.   JOURNAL OF CONTROLLED RELEASE

Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

(2016) Kelly D Moynihan et al.   NATURE MEDICINE

Learning from PD-1 Resistance: New Combination Strategies

(2016) Xia Bu et al.   TRENDS IN MOLECULAR MEDICINE

Endotoxin free hyaluronan and hyaluronan fragments do not stimulate TNF-α, interleukin-12 or upregulate co-stimulatory molecules in dendritic cells or macrophages

(2016) Yifei Dong et al.   Scientific Reports

Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases

(2015) Thanh-Huyen Tran et al.   CLINICAL IMMUNOLOGY

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

(2015) Jamie E. Rayahin et al.   ACS Biomaterials-Science & Engineering

Lipid Raft-Mediated Regulation of Hyaluronan–CD44 Interactions in Inflammation and Cancer

(2015) Toshiyuki Murai   Frontiers in Immunology

Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer

(2015) Suniti Misra et al.   Frontiers in Immunology

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

(2015) Jamie E. Rayahin et al.   ACS Biomaterials Science & Engineering

Hyaluronan digestion controls DC migration from the skin

(2014) Jun Muto et al.   JOURNAL OF CLINICAL INVESTIGATION

Many faces of DAMPs in cancer therapy

(2013) O Krysko et al.   Cell Death & Disease

Opposing effects of high- and low-molecular weight hyaluronan on CXCL12-induced CXCR4 signaling depend on CD44

(2013) K Fuchs et al.   Cell Death & Disease

Costimulatory Molecules on Immunogenic Versus Tolerogenic Human Dendritic Cells

(2013) Mario Hubo et al.   Frontiers in Immunology

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Therapeutic Targeting of Hyaluronan in the Tumor Stroma

(2012) Anne Kultti et al.   Cancers

Low molecular weight hyaluronan preconditioning of tumor-pulsed dendritic cells increases their migratory ability and induces immunity against murine colorectal carcinoma

(2011) Laura Alaniz et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

DAMPening Inflammation by Modulating TLR Signalling

(2010) A. M. Piccinini et al.   MEDIATORS OF INFLAMMATION

Altered Hyaluronan Biosynthesis and Cancer Progression: an Immunological Perspective

(2010) Laura Alaniz et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Enzymatic Depletion of Tumor Hyaluronan Induces Antitumor Responses in Preclinical Animal Models

(2010) C. B. Thompson et al.   MOLECULAR CANCER THERAPEUTICS

Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities

(2009) B. P. Toole   CLINICAL CANCER RESEARCH

CD44 Costimulation Promotes FoxP3+ Regulatory T Cell Persistence and Function via Production of IL-2, IL-10, and TGF- 

(2009) P. L. Bollyky et al.   JOURNAL OF IMMUNOLOGY

Blocking TLR2 Activity Attenuates Pulmonary Metastases of Tumor

(2009) Hong-Zhen Yang et al.   PLoS One

Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and progression

(2008) Naoki Itano et al.   CANCER SCIENCE

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE