TRIB1 is a positive regulator of hepatocyte nuclear factor 4-alpha

Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease

(2017) Patrick A. Eyers et al.   TRENDS IN CELL BIOLOGY

Role of Tribbles Pseudokinase 1 (TRIB1) in human hepatocyte metabolism

(2016) Sébastien Soubeyrand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

From Loci to Biology

(2016) Sylvia T. Nurnberg et al.   CIRCULATION RESEARCH

TRIB1 Is Regulated Post-Transcriptionally by Proteasomal and Non-Proteasomal Pathways

(2016) Sébastien Soubeyrand et al.   PLoS One

Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathways

(2016) Hongtao Guan et al.   Scientific Reports

The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner

(2015) Fiona P. Bailey et al.   BIOCHEMICAL JOURNAL

Tribbles-1: a novel regulator of hepatic lipid metabolism in humans

(2015) R. C. Bauer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Extensive variation between tissues in allele specific expression in an outbred mammal

(2015) Amanda J. Chamberlain et al.   BMC GENOMICS

Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα

(2015) Robert C. Bauer et al.   JOURNAL OF CLINICAL INVESTIGATION

Sin3A-associated protein, 18 kDa, a novel binding partner of TRIB1, regulatesMTTPexpression

(2015) Saho Makishima et al.   JOURNAL OF LIPID RESEARCH

Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 Pseudokinase

(2015) James M. Murphy et al.   STRUCTURE

TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions

(2014) Yuumi Ishizuka et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks

(2014) Jean-Philippe Babeu   WORLD JOURNAL OF GASTROENTEROLOGY

Functional Analysis of the TRIB 1 Associated Locus Linked to Plasma Triglycerides and Coronary Artery Disease

(2014) Adrianna Douvris et al.   Journal of the American Heart Association

Cooperativity and Rapid Evolution of Cobound Transcription Factors in Closely Related Mammals

(2013) Klara Stefflova et al.   CELL

The Tribbles-1 Protein in Humans: Roles and Functions in Health and Disease

(2013) E. Dugast et al.   CURRENT MOLECULAR MEDICINE

Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia

(2012) T. Yokoyama et al.   BLOOD

Genetic Basis of Atherosclerosis: Insights From Mice and Humans

(2012) Ioannis M. Stylianou et al.   CIRCULATION RESEARCH

Suppression of Hepatocyte Proliferation by Hepatocyte Nuclear Factor 4α in Adult Mice

(2012) Jessica A. Bonzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

SUMOylation of HNF4  regulates protein stability and hepatocyte function

(2012) W. Zhou et al.   JOURNAL OF CELL SCIENCE

NR2F1 disrupts synergistic activation of theMTTPgene transcription by HNF-4α and HNF-1α

(2012) Kezhi Dai et al.   JOURNAL OF LIPID RESEARCH

IL1β Down-regulation of Sex Hormone-Binding Globulin Production by Decreasing HNF-4α Via MEK-1/2 and JNK MAPK Pathways

(2012) Rafael Simó et al.   MOLECULAR ENDOCRINOLOGY

The stable repression of mesenchymal program is required for hepatocyte identity: A novel role for hepatocyte nuclear factor 4α

(2011) Laura Santangelo et al.   HEPATOLOGY

Association of the TRIB1 tribbles homolog 1 gene rs17321515 A>G polymorphism and serum lipid levels in the Mulao and Han populations

(2011) Lynn Aung et al.   Lipids in Health and Disease

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

Hepatic Hepatocyte Nuclear Factor 4α Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis

(2010) Liya Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differential ability of Tribbles family members to promote degradation of C/EBP  and induce acute myelogenous leukemia

(2010) P. H. Dedhia et al.   BLOOD

Human Tribbles homolog 1 functions as a negative regulator of retinoic acid receptor

(2010) Masamichi Imajo et al.   GENES TO CELLS

Trib1 is a lipid- and myocardial infarction–associated gene that regulates hepatic lipogenesis and VLDL production in mice

(2010) Ralph Burkhardt et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population

(2010) M.-H. Park et al.   JOURNAL OF MEDICAL GENETICS

What are nuclear receptor ligands?

(2010) Frances M. Sladek   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Common variants at 30 loci contribute to polygenic dyslipidemia

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

(2008) Sekar Kathiresan et al.   NATURE GENETICS