Asymmetric vinylogous aldol addition of alkylidene oxindoles on trifluoromethyl-α,β-unsaturated ketones

Enantioselective Synthesis of Trifluoromethyl α,β-Unsaturated δ-Lactones via Vinylogous Aldol-Lactonization Cascade

(2018) Simone Crotti et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Organocatalyzed Vinylogous Michael Reactions of 3-Alkylidene Oxindoles with Enals

(2017) Junjun Feng et al.   JOURNAL OF ORGANIC CHEMISTRY

Mechanism and Origins of Stereoselectivity in the Cinchona Thiourea- and Squaramide-Catalyzed Asymmetric Michael Addition of Nitroalkanes to Enones

(2017) Matthew N. Grayson   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Enantioselective Cross-Aldol Reaction of o-Hydroxyarylketones and Trifluoromethyl Ketones

(2017) Pei Wang et al.   ORGANIC LETTERS

Enolizable Alkylidene Heterocyclic and Carbocyclic Carbonyl Systems­: Valuable Vinylogous Donor Substrates in Synthesis

(2017) Andrea Sartori et al.   SYNTHESIS-STUTTGART

Part I: Diastereoselective Reactions Involving β-Mono- and β,β′-Disubstituted Alkylidene Oxindoles: Pondering Alkene Geometry

(2017) Madhu Ganesh et al.   Asian Journal of Organic Chemistry

Enantioselective Vinylogous Organocascade Reactions

(2016) Hamish B. Hepburn et al.   CHEMICAL RECORD

Cinchona Urea-Catalyzed Asymmetric Sulfa-Michael Reactions: The Brønsted Acid−Hydrogen Bonding Model

(2016) Matthew N. Grayson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An asymmetric allylic alkylation reaction of 3-alkylidene oxindoles

(2015) Junjun Feng et al.   CHEMICAL COMMUNICATIONS

Direct asymmetric vinylogous Michael addition of 3-alkylidene oxindoles to chalcones catalyzed by a chiral N,N′-dioxide ytterbium(iii) complex

(2015) Xiao Xiao et al.   CHEMICAL COMMUNICATIONS

Vinylogous Reactivity of Oxindoles Bearing Nonsymmetric 3-Alkylidene Groups

(2015) Nicola Di Iorio et al.   JOURNAL OF ORGANIC CHEMISTRY

Decarboxylative Fluorination of Aliphatic Carboxylic Acids via Photoredox Catalysis

(2015) Sandrine Ventre et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Vinylogous Diels-Alder Reactions Catalyzed by a Chiral Phosphoric Acid

(2014) Xu Tian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions

(2014) Xiaoyu Yang et al.   CHEMICAL REVIEWS

Remote Control of Axial Chirality: Aminocatalytic Desymmetrization of N-Arylmaleimides via Vinylogous Michael Addition

(2014) Nicola Di Iorio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Enantioselective Organocatalyzed Vinylogous Michael-Type Reaction for the Construction of Trifluoromethylated All-Carbon Quaternary Stereocenters

(2014) Qiao Chen et al.   ORGANIC LETTERS

Asymmetric Synthesis of 3,3′-Spirooxindoles Fused with Cyclobutanes through Organocatalytic Formal [2 + 2] Cycloadditions under H-Bond-Directing Dienamine Activation

(2014) Liang-Wen Qi et al.   ORGANIC LETTERS

Enantioselective Primary Amine Catalyzed Aldol-Type Construction of Trifluoromethylated Tertiary Alcohols

(2014) Li Li et al.   SYNLETT

Organocatalytic [4+2] addition reactions via tetraenamine intermediate

(2014) Julian Stiller et al.   Chemical Science

Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies

(2014) Daojuan Cheng et al.   ACS Catalysis

Organocatalytic asymmetric vinylogous Michael addition of 3-alkylidene oxindoles to α-substituted β-nitroacrylates: facile construction of a chiral all-carbon quaternary center

(2014) Yuan Zhong et al.   RSC Advances

Controlling the Molecular Topology of Vinylogous Iminium Ions by Logical Substrate Design: Highly Regio- and Stereoselective Aminocatalytic 1,6-Addition to Linear 2,4-Dienals

(2013) Mattia Silvi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Synthesis of Allylic Alcohols and Derivatives and their Applications in Organic Synthesis

(2013) Alexandre Lumbroso et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

When asymmetric aminocatalysis meets the vinylogy principle

(2013) Igor D. Jurberg et al.   CHEMICAL COMMUNICATIONS

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Palladium-Catalyzed Allylic C–H Fluorination

(2013) Marie-Gabrielle Braun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Beyond Classical Reactivity Patterns: Shifting from 1,4- to 1,6-Additions in Regio- and Enantioselective Organocatalyzed Vinylogous Reactions of Olefinic Lactones with Enals and 2,4-Dienals

(2013) Luca Dell’Amico et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of 9-amino(9-deoxy)epi cinchona alkaloids, general chiral organocatalysts for the stereoselective functionalization of carbonyl compounds

(2013) Carlo Cassani et al.   Nature Protocols

Isothiourea-mediated asymmetric Michael-lactonisation of trifluoromethylenones: a synthetic and mechanistic study

(2013) Louis C. Morrill et al.   Chemical Science

Aminocatalytic remote functionalization strategies

(2013) Hao Jiang et al.   Chemical Science

A Polycomponent Metal-Catalyzed Aliphatic, Allylic, and Benzylic Fluorination

(2012) Steven Bloom et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trienamine Catalysis with 2,4-Dienones: Development and Application in Asymmetric Diels-Alder Reactions

(2012) Xiao-Feng Xiong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bifunctional Cinchona Alkaloid/Thiourea Catalyzes Direct and Enantioselective Vinylogous Michael Addition of 3-Alkylidene Oxindoles to Nitroolefins

(2012) Claudio Curti et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

(2012) Renato Dalpozzo et al.   CHEMICAL SOCIETY REVIEWS

Highly Enantioselective Organocatalytic Trifluoromethyl Carbinol Synthesis—A Caveat on Reaction Times and Product Isolation

(2012) Nongnaphat Duangdee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Enantioselective Alkynylation of Trifluoromethyl Ketones: Pronounced Metal Fluoride Effects and Implications of Zinc-to-Titanium Transmetallation

(2011) Guang-Wu Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Vinylogous Aldol and Related Addition Reactions: Ten Years of Progress†

(2011) Giovanni Casiraghi et al.   CHEMICAL REVIEWS

Squaramides: Bridging from Molecular Recognition to Bifunctional Organocatalysis

(2011) José Alemán et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Organocatalytic Vinylogous Aldol Reaction: Recent Advances

(2011) Sunil V. Pansare et al.   CHEMISTRY-A EUROPEAN JOURNAL

3-Alkenyl-2-silyloxyindoles: An Enabling, Yet Understated Progeny of Vinylogous Carbon Nucleophiles

(2011) Gloria Rassu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Construction of Tertiary Alcohols Bearing Perfluoroalkyl Chains Catalyzed by Prolinamide-Thioureas

(2011) Christoforos G. Kokotos   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Organocatalytic α-Fluorination of Cyclic Ketones

(2011) Piotr Kwiatkowski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trienamines in Asymmetric Organocatalysis: Diels−Alder and Tandem Reactions

(2011) Zhi-Jun Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-(Heteroarenesulfonyl)prolinamides-Catalyzed Aldol Reaction between Acetone and Aryl Trihalomethyl Ketones

(2011) Noriyuki Hara et al.   ORGANIC LETTERS

A New Class of Urea-Substituted Cinchona Alkaloids Promote Highly Enantioselective Nitroaldol reactions of Trifluoromethylketones

(2011) Carole Palacio et al.   ORGANIC LETTERS

3-Alkenyl-oxindoles: Natural Products, Pharmaceuticals, and Recent Synthetic Advances in Tandem/Telescoped Approaches

(2010) Alessia Millemaggi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Fluorine in health care: Organofluorine containing blockbuster drugs

(2010) David O’Hagan   JOURNAL OF FLUORINE CHEMISTRY

Direct asymmetric vinylogous Michael addition of cyclic enones to nitroalkenes via dienamine catalysis

(2010) G. Bencivenni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly enantio- and diastereoselective synthesis of α-trifluoromethyldihydropyrans using a novel bifunctional piperazine-thiourea catalyst

(2009) Peng Li et al.   CHEMICAL COMMUNICATIONS

Enantioselective α-Trifluoromethylation of Aldehydes via Photoredox Organocatalysis

(2009) David A. Nagib et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric catalysis with bifunctional cinchona alkaloid-based urea and thiourea organocatalysts

(2008) Stephen J. Connon   CHEMICAL COMMUNICATIONS

Asymmetric synthesis of either diastereomer of trifluoromethylated allylic amines by the selective reduction of trifluoromethyl α,β-unsaturated N-tert-butanesulfinyl ketoimines

(2008) Zhen-Jiang Liu et al.   CHEMICAL COMMUNICATIONS

Enantioselective organocatalyzed Henry reaction with fluoromethyl ketones

(2008) Marco Bandini et al.   CHEMICAL COMMUNICATIONS

Transmission of stereochemical information over nanometre distances in chemical reactions

(2008) Jonathan Clayden   CHEMICAL SOCIETY REVIEWS

Chiral Squaramide Derivatives are Excellent Hydrogen Bond Donor Catalysts

(2008) Jeremiah P. Malerich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chirality-Sensing Supramolecular Systems

(2007) Guy A. Hembury et al.   CHEMICAL REVIEWS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS

An enantioselective nucleophilic addition of α,β-unsaturated trifluoromethylketones catalyzed by l-proline derivatives

(2007) Dehui Zhang et al.   TETRAHEDRON