Journal
TETRAHEDRON LETTERS
Volume 54, Issue 8, Pages 802-805Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.11.112
Keywords
Hydrazino acid; Hydrazino turn; Peptides; Azetidine; Ring opening reaction; Hydrogen bonding
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Funding
- French Ministry of Higher Education and Research
- COST [CM 0803]
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Peptide formation on the N-terminal of 1-aminoazetidine-2-carboxylic acid is rendered problematic due to a ring opening reaction. However C-terminal development is possible and two diastereomeric mixed hydrazino dipeptides were prepared. Solution-state studies of these compounds suggest the presence of intramolecular hydrogen bonding, consistent with a hydrazino turn, and the crystal structure of one of these compounds shows a horse-shoe conformation, centered around what appears to be a hydrazino turn involving three hydrogen bond acceptors. (C) 2012 Elsevier Ltd. All rights reserved.
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