Journal
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume 36, Issue 2, Pages 245-252Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.115.306255
Keywords
histological techniques; models; animal; molecular imaging; venous thrombosis
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Funding
- British Heart Foundation
- National Institute for Health Research
- Circulation Foundation
- Academy of Medical Sciences (AMS) [AMS-SGCL12-Saha] Funding Source: researchfish
- British Heart Foundation [FS/11/37/28819] Funding Source: researchfish
- National Institute for Health Research [CL-2011-17-006] Funding Source: researchfish
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Deep vein thrombosis and common complications, including pulmonary embolism and post-thrombotic syndrome, represent a major source of morbidity and mortality worldwide. Experimental models of venous thrombosis have provided considerable insight into the cellular and molecular mechanisms that regulate thrombus formation and subsequent resolution. Here, we critically appraise the ex vivo and in vivo techniques used to assess venous thrombosis in these models. Particular attention is paid to imaging modalities, including magnetic resonance imaging, micro-computed tomography, and high-frequency ultrasound that facilitate longitudinal assessment of thrombus size and composition.
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