Journal
NATURAL PRODUCT RESEARCH
Volume 27, Issue 23, Pages 2251-2255Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2013.821120
Keywords
(-)-arctigenin; structure modification; synthetic derivatives; anticancer bioactivity
Categories
Funding
- National Eleventh Five-year Plan in R&D of Important New Medicine [2009ZX09103-423]
- Shenyang City Science and Technology Project [F11-264-1-20]
- Program for Liaoning Innovative Research Team in University [LT2013020]
Ask authors/readers for more resources
(-)-Arctigenin, an important active constituent of the traditional Chinese herb Fructus Arctii, was found to exhibit various bioactivities, so it can be used as a good lead compound for further structure modification in order to find a safer and more potent medicine. (-)-Arctigenin derivatives 1-5 of (-)-arctingen were obtained by modifying with ammonolysis at the lactone ring and sulphonylation at C (6) and C (6) and O-demethylation at CH3O-C (3), CH3O-C (3) and CH3O-C (4), and their anticancer bioactivities were examined.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
