Article
Dermatology
Anke S. Lonsdorf, Aric Keller, Julia Hartmann, Alexander H. Enk, Patrick Gholam
Summary: This study evaluated the efficacy and tolerability of low-irradiance photodynamic therapy combined with Er:YAG pretreatment compared to conventional photodynamic therapy in the treatment of actinic keratoses in organ transplant recipients. The results showed that low-irradiance photodynamic therapy combined with Er:YAG pretreatment achieved a significantly superior lesion response rate without negatively impacting pain or cosmetic outcome.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Dermatology
Sigrid Karrer, Rolf-Markus Szeimies, Wolfgang G. Philipp-Dormston, Peter A. Gerber, Welf Prager, Elisabeth Datz, Florian Zeman, Karolina Mueller, Michael Koller
Summary: This study investigated the preventive potential of daylight photodynamic therapy for actinic keratoses and found that it was more effective in reducing new lesions compared to cryosurgery. Additionally, it significantly improved various signs of photoaging and resulted in less pain and fewer side effects. However, the prevention of actinic keratoses by this therapy could not be statistically proven in a reliable manner.
ACTA DERMATO-VENEREOLOGICA
(2021)
Article
Dermatology
Taylor A. Bullock, Jeffrey Negrey, Bo Hu, Christine B. Warren, Tayyaba Hasan, Edward Maytin
Summary: The study found that oral VD3 pretreatment significantly improves the clinical response of AK patients to PDT, and this treatment shows good tolerance.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Stefano Piaserico, Roberto Mazzetto, Emma Sartor, Carlotta Bortoletti
Summary: This study reviewed combination-based photodynamic therapy (PDT) treatments for multiple actinic keratoses (AKs), including topical, systemic, and mechanical-physical strategies. The study found that topical pretreatment with imiquimod, adapalene, 5-fluorouracil, and calcipotriol was more successful than PDT alone. Mechanical laser treatments and systemic treatment with Polypodium leucotomos were also effective.
Article
Optics
Shuzhan Shen, Yajing Cao, Jiandan Li, Xiaojing Liu, Zhongxia Zhou, Xiuli Wang, Peiru Wang
Summary: Rosacea and actinic keratosis have some clinical similarity and can coexist. Dermoscopy and reflectance confocal microscopy are useful for diagnosis and monitoring. Novel IPL-PDT may be more effective than traditional ALA-PDT. Combination therapy of IPL-PDT and oral minocycline improves rosacea and AK lesions.
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
(2022)
Article
Oncology
Hans Christian Wulf, Ida M. Heerfordt
Summary: This article introduces several ways to counteract the side effects of classic PDT, including simplifying procedures and changing treatment courses to reduce the burden on patients and clinics.
ANTICANCER RESEARCH
(2022)
Article
Dermatology
Jiandan Li, Yunfeng Zhang, Guolong Zhang, Linglin Zhang, Zhongxia Zhou, Peiru Wang, Xiuli Wang
Summary: The study aimed to explore the efficacy and pain tolerance of the modified painless PDT (M-PDT) in facial multiple actinic keratosis. The results showed that M-PDT is comparable to conventional PDT (C-PDT) in efficacy for treating facial multiple AK, with significantly lower pain scores reported by patients undergoing M-PDT.
LASERS IN SURGERY AND MEDICINE
(2023)
Article
Oncology
Clara Curiel-Lewandrowski, Caitlyn N. Myrdal, Kathylynn Saboda, Chengcheng Hu, Edith Arzberger, Giovanni Pellacani, Franz Josef Legat, Martina Ulrich, Petra Hochfellner, Margaret C. Oliviero, Paola Pasquali, Melissa Gill, Rainer Hofmann-Wellenhof
Summary: Non-invasive imaging technology, such as reflectance confocal microscopy, has the potential to enhance the evaluation of actinic keratoses (AKs) and monitor treatment responses over time. Standardized RCM protocols may enable better comparison across clinical trials and early detection of relapses.
Article
Engineering, Biomedical
Meital Oren-Shabtai, Nadezhda Sloutsky, Moshe Lapidoth, Daniel Mimouni, Ilia Chorny, Igor Snast, Yael Anne Leshem, Rivka Friedland, Emmilia Hodak, Ifat Klein, Yael Agmon, Assi Levi
Summary: This study evaluated the safety and efficacy of a thermomechanical fractional skin resurfacing technology for the treatment of facial and scalp actinic keratoses. The results showed that the Tixel device was effective in reducing the number of lesions and improving the overall appearance. Patients were highly satisfied with the treatment results and experience.
LASERS IN MEDICAL SCIENCE
(2022)
Review
Geriatrics & Gerontology
Piergiacomo Calzavara-Pinton, Irene Calzavara-Pinton, Chiara Rovati, Mariateresa Rossi
Summary: Actinic keratosis is a disease caused by excessive sun exposure, which needs to be treated to prevent the development of cancer. Different treatments, including physical ablative techniques and medication, are used for various lesions. There is no difference in treatment efficacy and tolerability between older and younger patients, but older patients often require more motivation for treatment.
Article
Dermatology
J. Hartmann, A. Keller, A. Enk, P. Gholam
Summary: This study observed the effects of conventional photodynamic therapy (c-PDT) and daylight photodynamic therapy (dl-PDT) on different hemodynamic parameters. The results showed that c-PDT caused more pain and hypertension, while dl-PDT was almost painless and did not lead to any changes in hemodynamic parameters. Both treatments had a similar lesion response rate after one month. Therefore, dl-PDT may be a more favorable treatment option.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Oncology
Stefano Piaserico, Antonella Piccioni, Carlota Gutierrez Garcia-Rodrigo, Giorgia Sacco, Cristina Pellegrini, Maria Concetta Fargnoli
Summary: Topical calcitriol and methyl aminolevulinate (MAL) daylight photodynamic therapy (CAL-DL-PDT) showed higher efficacy for thicker actinic keratoses (AKs) on acral sites compared to placebo and MAL-DL-PDT (P-DL-PDT), especially for grouped grade II/III AKs. However, CAL-DL-PDT was associated with more frequent local skin reactions.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Oncology
M. Dubois, H. Abi Rached, F. Dezoteux, C. Maire, C. Vicentini, H. Behal, E. Thecua, F. Lecomte, S. Mordon, L. Mortier
Summary: This study confirms the efficacy and safety of textile PDT using the FLUXMEDICARE device in treating AKs on the scalp and temples, with excellent tolerance and minimal pain reported.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Dermatology
Maryam Nasimi, Maryam Ghiasi, Vahideh Lajevardi, Fatemeh Nasiri, Safoura Shakoei
Summary: The study compared the efficacy of combining fractional Er: YAG laser and Kligman's formula with using Kligman's formula alone in treating melasma. The combination treatment showed significant improvement in reducing MASI scores and cheek Visioface scores compared to using Kligman's formula alone.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Dermatology
Jon Chim Bai-Habelski, Annette Ko, Christoph Ortland, Marcus Stocker, Andrea Ebeling, Uwe Reinhold
Summary: Photodynamic therapy with 5-aminolevulinic acid hydrochloride is an established method for treating actinic keratosis (AK). Occlusion during ALA incubation can improve the clinical outcome of PDT for AK on hands and arms. Two PD P 506 A-PDT sessions 1-2 weeks apart are an efficacious treatment for AK on hands and arms.
EXPERIMENTAL DERMATOLOGY
(2022)