Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β

GSK3β Phosphorylates Newly Identified Site in the Proline-Alanine–Rich Region of Cardiac Myosin–Binding Protein C and Alters Cross-Bridge Cycling Kinetics in Human

(2013) Diederik W. D. Kuster et al.   CIRCULATION RESEARCH

Signaling effectors underlying pathologic growth and remodeling of the heart

(2013) Jop H. van Berlo et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiple Reaction Monitoring to Identify Site-Specific Troponin I Phosphorylated Residues in the Failing Human Heart

(2012) Pingbo Zhang et al.   CIRCULATION

Subcellular Structures and Function of Myocytes Impaired During Heart Failure Are Restored by Cardiac Resynchronization Therapy

(2012) Frank B. Sachse et al.   CIRCULATION RESEARCH

AMP-activated Protein Kinase Phosphorylates Cardiac Troponin I at Ser-150 to Increase Myofilament Calcium Sensitivity and Blunt PKA-dependent Function

(2012) Benjamin R. Nixon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electrical Remodeling in Dyssynchrony and Resynchronization

(2012) Takeshi Aiba et al.   Journal of Cardiovascular Translational Research

A Critical Function for Ser-282 in Cardiac Myosin Binding Protein-C Phosphorylation and Cardiac Function

(2011) Sakthivel Sadayappan et al.   CIRCULATION RESEARCH

Redox Regulation of Mitochondrial ATP Synthase

(2011) Sheng-Bing Wang et al.   CIRCULATION RESEARCH

Incomplete Recovery of Myocyte Contractile Function Despite Improvement of Myocardial Architecture With Left Ventricular Assist Device Support

(2011) Amrut V. Ambardekar et al.   Circulation-Heart Failure

The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial

(2011) John GF Cleland et al.   LANCET

Old and New Intravenous Inotropic Agents in the Treatment of Advanced Heart Failure

(2011) Marco Metra et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

(2011) F. I. Malik et al.   SCIENCE

G s-Biased  2-Adrenergic Receptor Signaling from Restoring Synchronous Contraction in the Failing Heart

(2011) K. Chakir et al.   Science Translational Medicine

Relationship of Echocardiographic Dyssynchrony to Long-Term Survival After Cardiac Resynchronization Therapy

(2010) John Gorcsan et al.   CIRCULATION

Heart Failure–Associated Changes in RNA Splicing of Sarcomere Genes

(2010) Sek Won Kong et al.   Circulation-Cardiovascular Genetics

Protein kinase A–induced myofilament desensitization to Ca2+as a result of phosphorylation of cardiac myosin–binding protein C

(2010) Peter P. Chen et al.   JOURNAL OF GENERAL PHYSIOLOGY

Molecular basis of hereditary cardiomyopathy: abnormalities in calcium sensitivity, stretch response, stress response and beyond

(2010) Akinori Kimura   JOURNAL OF HUMAN GENETICS

Why does troponin I have so many phosphorylation sites? Fact and fancy

(2010) R. John Solaro et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Protein kinase C α and ε phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardium

(2009) Viola Kooij et al.   BASIC RESEARCH IN CARDIOLOGY

Electrophysiological Consequences of Dyssynchronous Heart Failure and Its Restoration by Resynchronization Therapy

(2009) Takeshi Aiba et al.   CIRCULATION

Mechanisms of Enhanced β-Adrenergic Reserve From Cardiac Resynchronization Therapy

(2009) Khalid Chakir et al.   CIRCULATION

Left Ventricular and Myocardial Function in Mice Expressing Constitutively Pseudophosphorylated Cardiac Troponin I

(2009) Jonathan A. Kirk et al.   CIRCULATION RESEARCH

Cardiac Resynchronization Therapy Corrects Dyssynchrony-Induced Regional Gene Expression Changes on a Genomic Level

(2009) Andreas S. Barth et al.   Circulation-Cardiovascular Genetics

Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy

(2009) David Hassel et al.   NATURE MEDICINE

Reversal of Global Apoptosis and Regional Stress Kinase Activation by Cardiac Resynchronization

(2008) Khalid Chakir et al.   CIRCULATION

HDAC4 and PCAF Bind to Cardiac Sarcomeres and Play a Role in Regulating Myofilament Contractile Activity

(2008) Mahesh P. Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Troponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: Increased or decreased?

(2008) Steven B. Marston et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Early and late effects of cardiac resynchronization therapy on force–frequency relation and contractility regulating gene expression in heart failure patients

(2007) Wilfried Mullens et al.   HEART RHYTHM