Neuropathic pain correction method using mesenchymal stem cells and cannabinoid receptor CB2 stimulation.

Authors

Anna-Maria V. Yerofeyeva¹ , Sergey V. Pinchuk² , Svetlana N. Rjabceva¹ , Alla Yu. Molchanova¹

1. Institute of Physiology NAS of Belarus
2. Institute of Biophysics and Cell Engineering NAS of Belarus

Conference / event

International Scientific Conference "Fundamental and Applied Sciences to Medicine", October 2022 (Minsk, Belarus)

Poster summary

Peripheral neuropathic pain is chronic pain due to damage or dysfunction of the peripheral nervous system. Mesenchymal stem cell (MSCs) transplantation is positioned as an effective treatment for neuropathic pain. Cannabinoid receptors CB1 and CB2 may be involved in MSC's actions, and their stimulation will possibly improve the effects of MSCs. In an in vivo experiment, we determined the mode of ADMSCs administration with the most pronounced and long-lasting analgesic effect in rats with neuropathic pain (NP). We have found an increase in the analgesic effect of ADMSCs through additional action on cannabinoid CB2 receptors, activated either on stem cells or in the area of sciatic nerve injury.

Keywords

Mesenchymal stem cells, Neuropathic pain, Cannabioid receptor, Catwalk

Research areas

Anatomy and Physiology, Neuroscience, Molecular and Cellular Biosciences

References

1. Bouhassira D. Rev Neurol, 2019;175,1-2: 16-25.
2. Rull T. et al. J Tissue Eng Regen Med, 2021;15: 88-98.
3. Yerofeyeva A.-M. et al. Surgery News, 2021; 29, 5: 527-534.

Funding

No data provided

Supplemental files

No data provided

Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

Creative Commons license

Copyright © 2023 Yerofeyeva et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.