The development of novel biomarkers for the diagnosis and prognosis of colorectal cancer

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Authors

Abinaya G.P¹ , Iyshwarya B K¹ , Ramakrishnan V¹

1. Chettinad Academy of Research and Education

Conference / event

International Conference on Current Trends in Biomedical Research (ICTBR), September 2022 (Chennai, India)

Poster summary

Colorectal cancer (CRC) is the third most commonly detected cancer and the fourth cause of mortality globally. The cancer originates in the digestive tract’s lower end i.e. the colon and rectum which begin as a non-cancerous polyp and turns out to be a tumor (sarcoma) in the later stages. The major aspects responsible are dysfunction of signaling mechanisms, alternation in methylation of various pathways leading to characteristic symptoms such as rectal bleeding, abdominal discomfort. They are sequences of DNA which are associated with the pre-disposition of a disease for instance exosomes, long non-coding RNA, methylated vimentin, etc. are some of the novel biomarkers used in the detection of colorectal cancer. The carcinoembryonic antigen (CEA) is a highly suggested prognostic marker because the level of CEA increases with the increase in CRC.

Keywords

Colorectal cancer, Biomarkers, Exosomes, MicroRNA, Carcinoembryonic antigen

Research areas

Genetics

References

No data provided

Funding

No data provided

Supplemental files

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Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

Data sharing not applicable to this poster as no datasets were generated or analyzed during the current study.

Creative Commons license

Copyright © 2022 G.P et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.