A possible role of arsenic exposure in diabetes and obesity

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Authors

Abinaya Girisankar Prema¹ , Iyshwarya Bhaskar Kalarani¹ , Ramakrishnan Veerabathiran¹

1. Chettinad Academy of Research and Education

Conference / event

CODI Controversies inObesity & Diabetes, October 2022 (Virtual)

Poster summary

In the modern world, obesity and diabetes are the most prevalent diseases. Around 39% of adults worldwide are obese and approximately 422 million are diabetics, according to the WHO. A complex disease, obesity is caused by body fat accumulation and a body mass index of 30 kg/m2 or higher. People who consume too much energy store the excess energy as glycogen in their adipose tissues, resulting in insulin resistance. By generating free radicals and inhibiting anti- oxidants, it elevates reactive oxygen species and causes oxidative stress. A major role that melatonin plays as a therapy for arsenic-induced diabetes is as a free radical scavenger. Pineal glands release melatonin, which has a lipophilic nature and can pass through all intracellular organs, preventing lipid peroxidation, reducing oxidative stress, and preventing cell death. Researchers are testing microRNA regulators as well as resveratrol to see if they can control arsenic-induced diabetes.

Keywords

Obesity, Diabetes, Arsenic, Insulin resistance, Melatonin, Oxidative stress

Research areas

Genetics

References

No data provided

Funding

No data provided

Supplemental files

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Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

Data sharing not applicable to this poster as no datasets were generated or analyzed during the current study.

Creative Commons license

Copyright © 2022 Girisankar Prema et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.