Stem cell technology to cure age-related macular degeneration (AMD)

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Authors

Kruthica Jaganathan Geethalakshmi¹ , Iyshwarya Bhaskar Kalarani¹ , Ramakrishnan Veerabathiran¹

1. Chettinad Academy of Research and Education

Conference / event

Chettinad Academy of Research and Education, October 2022 (Chettinad Health City, India)

Poster summary

Age-related macular degeneration (AMD) is a disorder that affects the retinal pigment epithelium which is a multifunctional monolayer of hexagonal cells at the back of the eye. The loss of retinal pigment epithelium (RPE) cells in age-related macular degeneration (AMD) causes the demise of photoreceptors and everlasting blindness, RPE cell transplantation strives to cure or reverse vision loss by preventing the death of photoreceptor cells and the most prominent application is stem cell treatment in regenerative medicine. According to initial reports from clinical trials, transplanting RPE cells obtained from HPSCs can allow AMD patients to vision clear, as a proof-of-concept, RPE cell transplantation for treating other retinal degenerative diseases such as AMD, has long been demonstrated in human and animal studies involving primary RPE cells, although recent studies have concentrated on the transplantation of RPE cells made from human pluripotent stem cells (HPSC).

Keywords

Macular degeneration, Photoreceptors, Retina, Stem cells, Genetics

Research areas

Genetics

References

No data provided

Funding

No data provided

Supplemental files

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Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

Data sharing not applicable to this poster as no datasets were generated or analyzed during the current study.

Creative Commons license

Copyright © 2022 Jaganathan Geethalakshmi et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.