51 Views · 15 Downloads · ☆☆☆☆☆ 0.0

Genetic aspects of epilepsy

PUBLISHED November 01, 2022 (DOI: https://doi.org/10.54985/peeref.2211p2734634)



Abinaya Girisankar Prema1 , Iyshwarya Bhaskar Kalarani1 , Ramakrishnan Veerabathiran1
  1. Chettinad Academy of Research and Education

Conference / event

Chettinad Academy of Research and Education, October 2022 (Chettinad Health City, India)

Poster summary

Epilepsy or seizure disorder is a chronic illness caused by the electrical imbalance in brain which is ranked as the fourth most common neurodegenerative disorder. It is also noted that men are more prone than women because they are greatly exposed to factors like brain damage, head trauma and alcohol consumption. The experimental model of epilepsy is studied using the limbic system, the hippocampus, one of the most prevalent site of focal seizures which becomes hyper excitable and recently it has been discovered that the excitatory neurons stimulate the inhibitory neurons to inhibit the dentate granule cells. This mechanism of hyper excitability has been proven to co-exist in the brain of a person suffering from epilepsy. If the seizures are consequences of any known genetic defect, it is termed as genetic epilepsy. Each of these genes plays a significant role in various aspects of epilepsy.


Epilepsy, Neurodegenerative disorder, Dementia, Seizures, Brain damage

Research areas



No data provided


No data provided

Supplemental files

No data provided

Additional information

Competing interests
No competing interests were disclosed.
Data availability statement
Data sharing not applicable to this poster as no datasets were generated or analyzed during the current study.
Creative Commons license
Copyright © 2022 Girisankar Prema et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Girisankar Prema, A., Bhaskar Kalarani, I., Veerabathiran, R. Genetic aspects of epilepsy [not peer reviewed]. Peeref 2022 (poster).
Copy citation