Gloria Bartolo

United States Keck Graduate Institute

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Commented on Obesity stigmatisation from obesity researchers
Extremely upsetting to hear. Hope obesity researchers are more aware and cautious of their bias.

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Commented on Obesity: ERAD linked to obesity
Amazing find for age-associated obesity.

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Commented on Obesity Policy Spotlight: Childhood Obesity
How do childhood obesity rates vary across different socioeconomic regions?

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Commented on Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents
It would be amazing to see the efficacy of these drugs in vivo

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Commented on In vitro activity of nitroxoline against clinical isolates of Candida species
This drug can inhibit angiogenesis, gram-negative, gram-positive, biofilms, AND candida species?? What else can it do?!

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Commented on Cathepsin B inhibitors: Further exploration of the nitroxoline core
Amazing work was done on studying the analogs of nitroxoline.

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Commented on Nitroxoline: a broad-spectrum biofilm-eradicating agent against pathogenic bacteria
Wow, amazing finding! Especially if further demonstrated in clinical development.

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Commented on Nitroxoline induces apoptosis and slows glioma growth in vivo
Is nitroxoline given via injections normally, or only approved for oral use in humans?

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Commented on Susceptibility of carbapenemase-producing Enterobacterales (CPE) to nitroxoline
Have preclinical trials started for this drug?

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Commented on Nitroxoline: repurposing its antimicrobial to antitumor application
Are there any specific cancers where nitroxoline is more effective against? Also, has nitroxoline ever reached clinical trials yet?

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Commented on Gas gangrene-associated gliding motility is regulated by the Clostridium perfringens CpAL/VirSR system
Such an amazing link found between gliding, virulence and theCpAL regulatory network. Fascinating!

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Commented on The EngCP endo α-N-acetylgalactosaminidase is a virulence factor involved in Clostridium perfringens gas gangrene infections
In mutant bacterial strains of the EngCP endoα-N-acetylgalactosaminidase, is their virulence attenuated as seen here?