Gloria Bartolo

United States Keck Graduate Institute

3 Papers
0 Following
22 Followers

Article

Commented on The Drosophila Y chromosome affects heterochromatin integrity genome-wide
It would be very interesting to study the sex-specific heterochromatin differences across other Drosophila species.

Article

Commented on Chromosome-Wide Gene Silencing Initiates Y Degeneration in Drosophila
Is there a difference between the neo-Y chromosome, and the regular Y chromosome? Or are they the same (just a different name)?

Article

Commented on Positive and Purifying Selection on the Drosophila Y Chromosome
I assume the FDY gene was not studied because it's exclusive to Drosophila melanogaster?

Article

Commented on Mitochondrial-Y chromosome epistasis in Drosophila melanogaster
Very cool link between Drosophila Y chromosome and longevity.

Article

Commented on Lysophosphatidylcholine Promotes Phagosome Maturation and Regulates Inflammatory Mediator Production Through the Protein Kinase A–Phosphatidylinositol 3 Kinase–p38 Mitogen-Activated Protein Kinase Signaling Pathway During Mycobacterium tuberculosis Infection in Mouse Macrophages
Is there any reason to believe similar effects wouldn't be seen in other strains of tuberculosis?

Article

Commented on Involvement of the Mannose Receptor and p38 Mitogen-Activated Protein Kinase Signaling Pathway of the Microdomain of the Integral Membrane Protein after Enteropathogenic Escherichia coli Infection
I wonder if anyone has an idea of the effects on the intestinal microbial communities for MIMP directed therapies.

Article

Commented on HIV-1 Glycoprotein 41 Ectodomain Induces Activation of the CD74 Protein-mediated Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase Pathway to Enhance Viral Infection
Could this new receptor (CD74) for HIV-1 Glycoprotein 41 be a possible drug target candidate?

Article

Commented on Mitogen-activated protein kinase signaling pathway in oral cancer (Review)
Excellent review of MAPK and oral cancer. On average, how long does it take to confer resistance to MAPK targeted therapies, if only a single subpathway/family is targeted?

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Commented on Mitogen-activated protein kinase pathway in osteosarcoma
Are any other MAPKs of interest in osteosarcoma, such as JNK or p38?

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Commented on ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors
I wonder how such mutations would act in animal models. It would be very interesting to see!

Article

Commented on Clostridium perfringens and Clostridium septicum toxoid to control cellulitis in turkeys
If such turkeys are for consumption, what would be the effect of such toxins on humans?

Article

Commented on Early-life long-term exposure to ZnO nanoparticles suppresses innate immunity regulated by SKN-1/Nrf and the p38 MAPK signaling pathway in Caenorhabditis elegans
Always great to consider the effects of new technologies on the environment!

Article

Commented on Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection
Are similar MAPK-signaling immune responses seen in other mosquito species? Or other parasitic infections in mosquitoes?

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Commented on Neospora caninum Activates p38 MAPK as an Evasion Mechanism against Innate Immunity
What other functions is the GRA24 protein known to have, specifically during infection?

Article

Commented on The Pore-Forming Toxin β hemolysin/cytolysin Triggers p38 MAPK-Dependent IL-10 Production in Macrophages and Inhibits Innate Immunity
Very new interesting function for pore-forming toxins (PFTs). It would be interesting to do a screen of all PFTs, and see how they vary in MAPK responses.
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